By Horace W. Davenport
This booklet examines the historical past of experimental learn in gastric secretion and digestion. the writer identifies the clinical questions that experience occupied researchers and discusses the experiments that experience resulted in their suggestions. by means of setting apart features of experimental research and tracing their evolution through the years, the publication offers gastric physiologists and gastroenterologists with an effective knowing of the highbrow historical past in their box.
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Extra info for A History of Gastric Secretion and Digestion: Experimental Studies to 1975
The deviations became more obvious when I plotted gastric juice concentration against plasma concentration (Fig. 1-15B); there was clearly a discontinuity at 3 mN. Not knowing what to do with my data, I consulted a young professor of physics at Rochester named Lee DuBridge. 70) W1p (1-6) When I plotted the data according to equation ( l-2), they fitted a straight line at plasma concentrations below 3 mN but feil below the straight line at concentrations greaterthan 3 mN (Fig. 1-15C). At concentrations below 3 mN the gastric mucosa concentrates iodide; above that concentration, iodide in addition enters the gastric juice in replacement of chloride.
Gastric carbonic anhydrase. ) 35 36 / A HISTORY OF GASTRIC SECRETION AND DIGESTION Thiocyanate and Carbonic Anhydrase After I bad studied the secretion ofbromide and iodide, it was obvious that the next anion I should study was thiocyanate. I fed my pouch dogs sodium thiocyanate, stimulated them to secrete by subcutaneous injections ofhistamine, and attempted to collect their gastric juice. I was frustrated by the scantiness of secretion, and eventually I realized that thiocyanate was inhibiting acid secretion.
To explain thiocyanate inhibition, I made a set of assumptions: l. The rate of acid secretion is proportional to the rate at which carbonic acid is produced in the parietal cells. 2. The rate of production ofcarbon dioxidein the cells is maximal and constant under histamine stimulation. 3. The uncatalyzed rate of production of carbonic acid is negligible. 4. The rate of production of carbonic acid is proportional to the concentration of active carbonic anhydrase in the cells. 5. The two-component theory correctly describes the relation between the concentration of acid in gastric juice and the rate of secretion of acid.
A History of Gastric Secretion and Digestion: Experimental Studies to 1975 by Horace W. Davenport