Get A Comprehensive Guide to Toxicology in Preclinical Drug PDF

By Ali S. Faqi (Auth.)

ISBN-10: 0123878152

ISBN-13: 9780123878151

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Extra resources for A Comprehensive Guide to Toxicology in Preclinical Drug Development

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Determination of time-dependent inactivation of CYP3A4 in cryopreserved human hepatocytes and assessment of human drug-drug interactions. Drug Met Disp 2011;39:2219e32. Walsky RL, Obach RS. Validated assays for human Cytochrome P450 Activities. Drug Metab Dispos 2004;32:647e60. Mahmood I. Allometric issues in drug development. J Pharm Sci 2000;88:1101e6. Houston JB, Galetin A. Progress towards prediction of human pharmacokinetic parameters from in vitro technologies. Drug Metab Rev 2003;35:393e415.

Baillie TA, Cayen MN, Fouda H, Gerson RJ, Green JD, Grossman SJ, et al. Metabolites in safety testing. Tox Appl Pharmacol 2002;182:188e96. Schadt S, Chen L-A, Bischoff D. Evaluation of relative LC-MS response of metabolites to parent drug in LC/nanospray ionization mass spectrometry: Potential implication in MIST assessment. J Mass Spectrom 2011;46:1281e6. Mamyrin BA, Karataev VI, Shmikk DV, Zagulin VA. The massreflectron, a new nonmagnetic time-of-flight mass spectrometer with high resolution.

For example, the apparent volume of distribution for SensiparÒ, which is used in the treatment of secondary hyperparathyroidism, is approximately 1000e1200 L [12,13]. 2). When the volume of distribution is high and the corresponding plasma concentration is therefore low, the compound is said to be widely distributed. , adipose tissue. In contrast to the potentially high apparent volumes of distribution sometimes observed for small molecules, the distribution of monoclonal antibodies outside of the blood compartment is often limited [4,5].

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A Comprehensive Guide to Toxicology in Preclinical Drug Development by Ali S. Faqi (Auth.)


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